Synonym(s)
Idiopathic lenticular mucocutaneous pigmentation; Laugier-Hunziker-Baran syndrome; Pigmentation melanique lenticulaire essentielle de la muqueuse jugale et des lèvres
HistoryThis section has been translated automatically.
Hunziker and Laugier, 1970; Baran, 1979
DefinitionThis section has been translated automatically.
Syndrome characterized by light to dark brown, lenticular, sometimes diffuse patches of the cheek and lip mucosa, with longitudinal nail pigmentation in 50-60% of cases.
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EtiopathogenesisThis section has been translated automatically.
Unknown.
HistologyThis section has been translated automatically.
Hyperpigmentation of the epithelium, melanophages in the papillary body, no nevus cells.
Differential diagnosisThis section has been translated automatically.
See Table 1 under Melanonychia striata longitudinalis.
Differential diagnoses of diffuse oral mucosal and lip hyperpigmentation may be congenital (in the context of systemic diseases such as Peutz-Jeghers syndrome, McCune-Albright syndrome, LEOPARD syndrome or Name syndrome) or acquired (smoking, drug use or inflammatory processes).
Note: Although Laugier-Hunziker syndrome is defined as a benign disease without malignant potential, malignant melanoma should always be considered in differential diagnosis (Lambertini M et al. 2018).
LiteratureThis section has been translated automatically.
- Baran R (1979) Longitudinal melanotic streaks as a clue to Laugier-Hunziker syndrome. Arch Dermatol 115: 1448-1449
- Haneke E (1991) Laugier-Hunziker-Baran syndrome. Dermatologist 42: 512-515
- Kanwar AJ et al (2001) Laugier-Hunziker syndrome. J Dermatol 28: 54-57
- Lambertini M et al (2018) Oral melanoma and other pigmentations: when to biopsy? J Eur Acad Dermatol Venereol 32: 209 - 214.
- Laugier P, Hunziker N (1970) Essential lenticular melanic pigmentation of the lip and cheek mucosa. Arch Belg Dermatol Syphiligr 26: 391-399.
- Lenane P et al (2001) The Laugier-Hunziker syndrome. J Eur Acad Dermatol Venereol 15: 574-577
- Makhoul EN et al (2003) Familial Laugier-Hunziker syndrome. J Am Acad Dermatol 49: S143-145.
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Incoming links (7)
Idiopathic lenticular mucocutaneous pigmentation; Laugier-hunziker syndrome; Lentigines syndromes; Melanonychia; Melanonychia striata; Melanotic spots of the mucous membranes; Pigmentation melanique lenticulaire essentielle de la muqueuse jugale et des lèvres;Outgoing links (6)
Carney complex; Laugier-hunziker syndrome; Leopard syndrome; Mccune-albright syndrome; Melanonychia striata; Peutz-jeghers syndrome;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer