DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
Different specifications: 10-35 h.
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Pharmacodynamics (Effect)This section has been translated automatically.
Increased release and formation of γ-aminobutyrylic acid, which leads to paralysis of the parasites.
IndicationThis section has been translated automatically.
Therapy-resistant forms of scabies, onchocerciasis. Also successful with therapy-resistant head lice infestation.
Ivermectin is successfully used in a 1% cream application in inflammatory (demodex superimposed?) rosacea (preparation: Soolantra®).
Pregnancy/nursing periodThis section has been translated automatically.
Ivermectin is detectable in the mother's milk for up to 12 days.
Dosage and method of useThis section has been translated automatically.
- Adults and children > 5 years: 150-200 μg/kg KG p.o. as ED, for onchocerciasis, repeated every 12 months.
- Children < 5 years: 0,15 μg/kg KG, Wdh. every 6 months.
- In skabies, ivermectin should not be given in the morning but in the evening (at night the immature precursors of the mites migrate over the body surface!)
- Many authors recommend a second dose of Skabies after 14 days (this is contradicted by the statement that 70-100% of cases heal after a single dose!)
Standard concentrationThis section has been translated automatically.
The time of maximum serum level is 4-5 hours; the concentration after oral administration of 200 μg/kg bw is 30-46 μg/liter. Ivermectin is detected in the skin in relevant concentrations after oral administration. The maximum concentrations show a close correlation with the concentrations measured in serum (max. 4-8 hrs). In areas rich in sebaceous glands, the concentration is significantly increased compared to "non-seborrhoeic" areas.
Undesirable effectsThis section has been translated automatically.
ContraindicationThis section has been translated automatically.
Pregnancy.
PreparationsThis section has been translated automatically.
Mectizan; Stromectol (not approved in Germany, available from international pharmacies).
Ivermectin can also be used locally. Soolantra® is available as a finished drug.
Note(s)This section has been translated automatically.
Good oral absorption. Excretion primarily via the faeces. With regard to the bioavailability (reservoir in the horny layer) of ivermectin, it is important to note that washing processes (washing hands, bathing, showering) are restricted at most during the therapy period (3-5 days). No cleaning of clothes or bed linen during this period, and written information and consent of the patient is recommended before administration of ivermectin!
PatientinformationThis section has been translated automatically.
Remember! No food should be taken 2 hours before and after taking the medicine!
LiteratureThis section has been translated automatically.
- Haas N et al (2003) Inside-out application of ivermectin in skabies- a hypothesis. JDDG 1: 933-937
- Karthikeyan K (2005) Treatment of scabies: newer perspectives. Postgrade Med J 81: 7-11
- Lawrence G et al (2005) Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin. Bull World Health Organ 83: 34-42
- Nofal A et al (2010) Oral ivermectin against head lice: a comparison with 0.5% topical malathion lotion. JDDG 8: 985-989
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Ancylostomiasis; Cheyletiellosis; Demodex folliculitis; Filariasis; Filariasis lymphatic; Gnathostomiasis; Larva currens; Larva migrans; Loiasis; Mazzotti reaction; ... Show allAuthors
Last updated on: 29.10.2020
Author: 
Prof. Dr. med. Peter Altmeyer
Editor: Dr. med. Christian Martin Winter