Hyalohyphomycosis B49.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Under this name, rare, mostly opportunistically occurring fungal infections induced by numerous species and genera are summarized. The clinical findings of these infections do not so much define the clinical picture and name, but rather the various pathogens, which have in common "septated transparent hyphae without inherent color". The term "hyalophycomycosis" is in contrast to pheohyphomycosis, in which the hyphae are characterized by an inherent colour (see also black fungus or Dematiaceae).

Pathogen
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So far, 20 genera of fungi have been described as potential pathogens. The most important genera are:

Occurrence/Epidemiology
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Worldwide occurrence; mostly as an opportunistic infection in immunodeficiency. The fungi grow on plants and are partially apathogenic, but can also cause generalized mycoses.

Clinical features
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Different clinical pictures depending on the pathogen and location of the infection. A uniform clinical description of skin affections is not possible due to the different pathogens. Clinically, depending on the duration and localisation of the infection, red, less symptomatic, smooth or even verrucous papules and plaques, including ulcers, have been described. Infection of internal organs (e.g. lungs) is possible, as are septic images in immunocompromised patients.

Complication(s)
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Systemic infestation with septic disease processes.

Therapy
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Adapted according to the pathogen and the disease caused. Itraconazole: 2 times/day 200 mg p.o.; possibly in combination with a 5% Imiquimod cream (under foil bandage). Total duration of therapy: approx. 2-3 months.

Literature
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  1. Ajello L et al (1984) Nomeclature of human pathogenic fungi. In: Basics of Antiseptics: Verlag Volk und Gesundheit S 363-377
  2. Salfelder K et al (2000) Fungal infections in humans. Omnimed Verlag, Hamburg, Munich, S. 279-280

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Last updated on: 29.10.2020