Hepatitis e virus

RNA virus; transmission of the virus takes place faecal-orally, i.e. either through the intake of food contaminated by faeces or through contaminated drinking water. Transmission of the hepatitis E virus through blood or blood products is rare. The virus has so far been found mainly in India, Asia and Africa. Increasing number of infections in Europe.

Incubation period (ICZ): 5-6 weeks. Clinical course is similar to hepatitis A with subclinical and mild courses.

Test material: Serology 1-2ml serum

Direct detection: EDTA blood, stool material

Microbiological diagnostics:

Direct detection:

• PCR: detection of viral RNA in stool, EDTA blood or serum

Serological detection of AK:

• Anti-HEV IgM and IgG-AK in serum (immunoblot): IgM-AK prove fresh infection. Detection from the onset of the first symptoms, detectable for 3-6 months. IgG-AK persist for life. Not too reliable in immunocompromised persons.