Hamartoma, neurofollicular Q85.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Very rare adnexal tumor with hair follicle differentiation.

Localization
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Face, nose.

Clinical features
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Solitary occurring, skin-coloured, firm, 0.3-0.7 cm large papules. Clinically uncharacteristic. Random histological findings.

Histology
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Abnormally hyperplastic sebaceous gland-hair unit embedded in a broad fibromyxoidal stroma with interspersed S100 positive cells, cells expressing neuron-specific enolase and synaptophysin, as a sign of neurogenic differentiation.

Differential diagnosis
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Literature
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  1. Barr RJ et al (1989) Neurofollicular hamartoma: a light microscopic and immunohistochemical study. J Cutan Pathol 16: 336-441
  2. Sangueza OP et al (1994) Neurofollicular hamartoma. A new histogenetic interpretation. At J Dermatopathol 16: 150-154
  3. Nova MP et al (1991) Neurofollicular hamartoma. A clinicopathological study.Am J Dermatopathol 13: 459-462
  4. Xie DL et al (1999) Neurofollicular hamartoma with strong diffuse S-100 positivity: a case report. At J Dermatopathol 21: 253-255

Incoming links (1)

Fibrofolliculoma;

Outgoing links (2)

Fibrofolliculoma; Trichodiscom;

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020