DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
3 h
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IndicationThis section has been translated automatically.
Life threatening infections with the cytomegalovirus, especially CMV retinitis in AIDS.
Limited indicationThis section has been translated automatically.
Pregnancy, nursing, renal failure.
Dosage and method of useThis section has been translated automatically.
5 mg/kg bw/day i.v. over 3 weeks, followed by maintenance therapy with 6 mg/kg bw i.v. 5 days/week or 3 times/day 4 cps. at 250 mg p.o., if necessary alternating with foscarnet for 14 days.
Remember! The infusion must always be administered over one hour to keep NW low!
Undesirable effectsThis section has been translated automatically.
Severe neutropenia (correction of neutropenia with granulocyte colony stimulating factor and dose reduction by 30-50%, discontinuation at < 500/μl), thrombopenia, fever, headache, allergic reactions, gastrointestinal complaints, hyperhidrosis.
Notice! Under therapy and up to 3 months after discontinuation of the preparation, men and women must practice effective contraception!
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Neutropenia (< 500 cells/μl), thrombopenia (< 25,000 cells/μl), cytostatic therapy.
PreparationsThis section has been translated automatically.
Cymeven
TablesThis section has been translated automatically.
Major interactions of ganciclovir
amphotericin B |
Haematotoxicity ↑ |
Cephalosporins |
cerebral seizures ↑ |
Cotrimoxazole |
Haematotoxicity ↑ |
Dapson |
Haematotoxicity ↑, cerebral Krampfanfälle↑ |
Didanosine |
frequent pancreatitis, anaemia, blood formation disorders |
Doxorubicin |
Haematotoxicity ↑ |
Flucytosine |
Haematotoxicity ↑ |
β lactam antibiotics |
cerebral seizures ↑ |
Pentamidine i.v. |
hematotoxicity ↑ |
Zidovudine |
Haematotoxicity ↑ |
Cytostatics |
Haematotoxicity ↑ |
Prof. Dr. med. Peter Altmeyer