Synonym(s)
Bang's disease; Febris undulans bovina; M. Bang; undulant fever
HistoryThis section has been translated automatically.
Marston, 1861; Bruce, 1887; Bang, 1897
DefinitionThis section has been translated automatically.
Notifiable anthropozoonosis caused by infection with brucells (Gram-negative aerobic rods). S.u. Brucellosis.
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PathogenThis section has been translated automatically.
Mostly Brucella abortus.
Clinical featuresThis section has been translated automatically.
- After the stage of bacteremia with undulating fever, granulomatous inflammation occurs, especially in the lymph nodes, spleen and liver.
- Skin changes are rare (< 5% of cases): macular exanthema, also multiform; erythema nodosum is also possible. Lupus erythematosus-like facial lesions have also been described.
External therapyThis section has been translated automatically.
Symptomatically e.g. with lotio alba.
Internal therapyThis section has been translated automatically.
- Agent of choice is Doxycycline 2.5 mg/kg bw/day p.o. for 6 weeks. For severe infections, combination with rifampicin (e.g. 600-900 mg/day p.o.).
- Reservative: Streptomycin can be given additionally in severe cases, (e.g. Streptomycin-Heyl) 1.2 g i.m. over 2 weeks.
- Alternatively, cotrimoxazole (e.g. Eusaprim), gentamicin (e.g. Refobacin), gyrase inhibitors such as Ofloxacin (e.g. Tavanic) are used.
Progression/forecastThis section has been translated automatically.
In about 5-10% of the treated cases relapses occur. With therapy in the acute phase (during the first 3 months after infection) the chances of recovery are almost 100%, later 60-80%.
LiteratureThis section has been translated automatically.
- Bang B (1897) The etiology of infectious discarding. Z Veterinary Medicine 1: 241-278
- Bruce D (1887) Note on the discovery of a microorganism in Malta fever. Practitioner (London) 39: 161-170
- Marston JA (1861) Report on fever (Malta). Royal Army Med Dept Rep 3: 486-521
- Weber A (2004) Topical epidemiology of selected bacterial zoonoses. Public Health 66(Suppl1): 26-30
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Outgoing links (10)
Brucellosis (overview); Cotrimoxazole; Doxycycline; Erythema nodosum; Gentamicin; Gyrase inhibitors; Gyrase-Hemmer; Fluorchinolone; ; Lupus erythematosus (overview); Ofloxacin; Rifampicin; Streptomycin;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer