Synonym(s)
T-20
DefinitionThis section has been translated automatically.
Fusion inhibitor (entry inhibitor). Inhibitor of the fusion of HIV-1 with CD4+ target cells.
Pharmacodynamics (Effect)This section has been translated automatically.
Enfuvirtide binds to the HR1 (heptate-repeat 1) subunit of the viral glycoprotein gp 41 and thereby prevents the conformational change of gp 41 required for the infection of target cells and thus the approximation of the membranes of HIV-1 and target cell.
Notice!
Enfuvirtid is exclusively effective against HIV-1, there is no activity against HIV-2.You might also be interested in
IndicationThis section has been translated automatically.
In combination therapies for the treatment of HIV-1 infection in experienced patients with proven virus replication (viral load) despite HAART.
Pregnancy/nursing periodThis section has been translated automatically.
Should not be used during pregnancy and lactation (insufficient data available).
Complication(s)This section has been translated automatically.
Bacterial pneumonia.
Dosage and method of useThis section has been translated automatically.
2 times/day 90 mg (1 ml) s.c.
Undesirable effectsThis section has been translated automatically.
Often local reactions at the injection site (erythema, urtica).
PreparationsThis section has been translated automatically.
Fuzeon
Prof. Dr. med. Peter Altmeyer