Synonym(s)
DA Syndromes; Rheumatism Skin changes
DefinitionThis section has been translated automatically.
- Today, the collective term "rheumatism" covers diseases of the musculoskeletal system with a wide variety of causes, courses and therapeutic approaches. As systemic diseases, they can involve the integument to varying degrees or the integumentary changes can completely overlay the rheumatic affections. These clinical pictures apostrophized as dermatitis-arthritis syndromes (DA syndromes) cannot be addressed as a uniform disease group due to their great variability. This is understandable if one considers the multifactorial genesis of rheumatic clinical pictures. The skin symptoms themselves are often unspecific in nature, but can be macro- and also micromorphologically so characteristic that on the one hand they already allow a suspected diagnosis and on the other hand can be used as the main criterion or "leading symptom" of a rheumatic disease. This applies for example to psoriasis arthropathica, to the skin and mucous membrane alterations of the Reiter syndrome (Balanitis circinata, Keratoderma blenorrhagicum), to the M. Behçet (recurrent aphthae, genital ulcers, subcutaneous thrombophlebitis, sterile pustules, pathergy phenomenon), but also for some clinical pictures from the group of autoimmune diseases, the sweet syndrome and diseases from the group of vasculitides. It is important to know these monitoring symptoms or diseases in order to arrive at a reliable diagnosis in a synoptic evaluation.
- It should also be noted that sometimes it is only the complicated therapies of rheumatic diseases that lead to a dermatological symptomatology, such as the therapies with NSAIDs (urticaria, angioedema and vasculitides), glucocorticoids (skin atrophy and skin bleeding) or with immunosuppressive drugs (pyodermias, pyoderma gangraenosum, severe generalized HPV infections of the skin). These side effects can lead to diagnostic errors. For these reasons, every patient with unclear rheumatic symptoms must be questioned and examined in great detail.
ClassificationThis section has been translated automatically.
The following tabular compilation of the extremely heterogeneous group of dermatitis-arthritis syndromes evaluates the symptom constellation "skin and joint symptoms" with clinical diagnoses and leading symptoms.
- Classification of dermatitis-arthritis syndromes according to clinical diagnoses and leading symptoms:
- Accompanying arthritis and exanthema in viral infections (hepatitis B and C, rubella, parvovirus, etc.) (leading symptoms: exanthema)
- Dermatomyositis (polymyositis) (leading symptoms: muscle weakness, light-emphasized exanthema)
- Gout (leading symptoms: highly acute, mostly monoarticular arthritis, metatarsophalangeal joint of the big toe, tophi)
- HIV infection (leading symptoms: immunodeficiency, septic or reactive arthritis, hair leukoplakia, Kaposi's sarcoma; activation of other rheumatic diseases such as Reiter's syndrome, SLE, vasculitis)
- Lyme borreliosis (leading symptoms: erythema chronicum migrans, lymphadenosis cutis benigna, acrodermatitis chronica atrophicans; mono-, oligo- or polyarthritis, often knee joints; musculoskeletal syndrome).
- Polyarthroses (leading symptoms: typical pattern of infection on the fingers, siphon nodules)
- Postenteritic arthritis (leading symptoms: diarrhea in the medical history, mono- or oligoarticular arthritis; urticarial or maculo-papular exanthema)
- Systemic scleroderma (leading symptom; fibrosing skin changes, Raynaud's symptoms, esophageal sclerosis, pulmonary fibrosis)
- Psoriatic arthritis (leading symptoms: characteristic skin symptoms, psoriatic infestation pattern of the joints, terminal joints, infestation in the jet, oligoarthritis)
- Reiter's syndrome (leading symptoms: conjunctivitis, balanitis, urethritis, arthritis mono- or oligoarticular, keratoderma blenorrhagicum)
- Rheumatic fever (very rare!) (Main symptoms: fever, history of throat infection, erythema anulare rheumaticum, cardiac involvement, subcutaneous nodules)
- Sarcoidosis (leading symptoms: erythema nodosum, nodular or anular plaques of the skin, arthritis of the knee and ankle)
- SLE (leading symptoms: typical skin symptoms with light-stressed exanthema; chronic polyarthritis)
- Breastfeeding syndrome adultes (leading symptoms: recurrent fever, breastfeeding exanthema, arthritis, lymphadenopathy).
- Clinic and classification of dermatitis-arthritis syndromes (alphabetical order):
- Infectious and reactive dermatitis-arthritis syndromes (arthritis and spondylitis)
- acne fulminans
- AIDS (rheumatic symptoms of AIDS)
- Acute arthritis-dermatitis syndrome (meningococcus)
- Bowel Bypass Syndrome
- Brucellosis
- Dermatitis, rheumatoid, neutrophilic
- Erythema elevatum diutinum
- Erythema nodosum
- Lyme borreliosis
- Measles
- Mononucleosis, infectious
- S.a. Polyarthritis, chronic (rheumatoid arthritis)
- Purpura Beauty Enoch
- Reiter syndrome (acute, recurrent or chronic)
- Rheumatic fever with erythema anulare rheumaticum
- Rubella
- SAPHO Syndrome
- Scarlet fever
- syphilis acquisita
- Spondylarthritis
- Sporotrichosis
- Typhoid
- Yersiniosis.
- Etiologically unexplained dermatitis-arthritis syndromes:
- Amyloidosis
- Arthroosteitis, pustular
- Chauffard-Raymond Syndrome
- Churg-Strauss Granulomas
- CINCA syndrome
- Behcet, M.
- Enteritis regionalis, skin lesions
- Erythema exsudativum multiforme
- Erythromelalgia
- Fasciitis, eosinophilic
- cold urticaria, familial
- Kawasaki Syndrome
- livedo racemosa
- Lipogranulomatosis, disseminated
- psoriatic osteoarthropathy
- Panniculitis, neutrophilic, lobular
- Polyarteritis nodosa, systemic
- Polyarthritis, chronic (juvenile, seropositive) with positive rheumatoid factor and rheumatoid nodules
- Polyarthritis, chronic (juvenile, systemic form) with intermittent volatile exanthema (about 80% of cases)
- polymyalgia rheumatica
- Polyneuropathies (neuropathic arthropathy)
- Pustulose, subcorneal
- Reticulohistiocytosis, multicenter
- Sarcoidosis
- Sneddon syndrome
- Still syndrome (exanthema as in the juvenile type of chronic polyarthritis)
- Still Syndrome, adult (AOSD) (recurrent fever-accompanying urticarial exanthema in > 80%)
- Sudeck's disease
- Sweet syndrome (acute neutrophilic febrile dermatosis)
- Urticarial Vasculitis-Arthritis Syndrome
- Wegener's granulomatosis.
- Dermatitis-arthritis syndromes with suspected or known genetic defects:
- dermatoarthritis, familial histiocytic
- Ehlers-Danlos Syndrome
- Marfan syndrome
- Mediterranean fever, familial
- Mucopoylsaccharidoses
- infantile progeria
- Pseudoxanthoma elasticum
- Tumor Necrosis Factor Receptor Associated Periodic Syndrome.
- Dermatitis-arthritis syndromes in allergic reactions:
- Serum Disease
- Urticaria of the serum disease type
- Urticaria vasculitis
- Reactive arthritides in drug exanthema.
- Dermatitis-arthritis syndromes in autoimmune diseases and immune defects:
- Agammaglobulinemia, congenital, Bruton type
- Phospholipid antibody syndrome
- CREST syndrome
- Dermatomyositis
- Antisynthetase syndrome (Jo-1 syndrome)
- Lupus erythematosus, systemic
- Mixed connective tissue disease
- Pemphigus, IgA pemphigus
- Pemphigoid, bullous
- Polychondritis recidivans et atrophicans
- Sjögren's Syndrome
- Scleroderma, systemic
- Scleroderma, circumscripts
- Congenital and acquired immune and complement defects
- Vasculitis, hypocomplementary.
- Dermatitis-arthritis syndromes in degenerative joint diseases:
- mono- and polyarthrosis.
- Dermatitis-arthritis syndromes in metabolic and endocrinological diseases:
- Gout
- Acromegaly
- Hemochromatosis
- Hyper- and hypothyroidism
- Hyperparathyroidism
- diabetes mellitus
- Hyperlipoproteinemia
- Ochronosis.
- Dermatitis-arthritis syndromes in neoplasia:
- Marie Bamberger syndrome (hypertrophic osteoarthropathy).
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Acne fulminans; Acrodermatitis chronica atrophicans; Acromegaly; Adult onset still disease; Agammaglobulinemia C-chromosomal type bruton; Aids; Amyloidosis (overview); Antisynthetase syndrome; Behçet's disease; Borrelia lymphocytoma; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer