DefinitionThis section has been translated automatically.
Protein complex of fibrinogen, fibrin and fibronectin that precipitates in plasma after prolonged exposure to cold at 0-4 °C (12-48 hours) and can cause a wide variety of clinical manifestations.
EtiopathogenesisThis section has been translated automatically.
Infections, malignant, especially myeloproliferative processes, thromboembolic diseases, also idiopathic.
- Etiological classification of cryofibrinogenemia (varies according to Peter and Gross):
- Essential cryofibrinogenesis
- Paraneoplastic (often causes vasculopathies in the venous area: thrombophlebitis saltans et migrans).
- Parainfectious
- thrombophilia in ovulation inhibitors, problem pregnancies, antiphospholipid antibodies, protein S and C deficiency
- Arterial occlusive disease
- Collagenoses
- Cirrhosis of the liver
- Medication (e.g. INH)
- Metallic foreign bodies.
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Clinical featuresThis section has been translated automatically.
- Skin: Acrocyanosis, livedo, acral necrosis, edema, purpura, Raynaud's phenomenon, urticaria.
- General: Arthralgia, myalgia, glomerulonephritis, peripheral neuropathy.
LaboratoryThis section has been translated automatically.
Detection of cryofibrinogen.
TherapyThis section has been translated automatically.
Treatment of the underlying disease. Otherwise symptomatic therapy according to the clinic.
LiteratureThis section has been translated automatically.
- Brüning H et al (1991) Cryofibrinogenemia - successful therapy by fibrinogen reduction. dermatologist 42: 227-232
- Nash JW et al (2003) The histopathologic spectrum of cryofibrinogenemia in four anatomic sites. Skin, lung, muscle, and kidney. At J Clin Pathol 119: 114-122
- Peter HH et al (1995): Secondary vasculitides. In: Peter HH, Pichler WJ (Ed.) Clinical Immunology, Urban Schwarzenberg, S. 425-426
- van Geest AJ et al (1999) Familial primary cryofibrinogenemia. J Eur Acad Dermatol Venereol 12: 47-50
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Incoming links (4)
Cryopathies; Cryoproteinemia; Purpura in cryofibrinogenesis; Renal diseases skin changes;Outgoing links (7)
Acrocyanosis; Edema; Fibronectin; Livedo (overview); Purpura (overview); Raynaud's syndrome; Urticaria (overview);Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer