Cd28

Marker for: T cells, plasma cells, thymocytes

Structure: Membrane protein (44 kDa)

Note: CD28 is a complex molecule involved in the adhesion of T cells with B cells. CD28 is a surface protein in T cells and plasma cells, but not in immature B cells. CD28 is involved in the activation of T cells as a costimulator. It enhances the production of interleukin-4 and interleukin-10 in T cells upon T cell receptor activation with costimulation by CD40L.

CD4+ cells express the protein more frequently than CD8+ cells.

Application: FACS, IHC (G), IF

(see also below) Cluster of differentiation

BCD28 belongs to the pro-inflammatory (inflammation-increasing) immune checkpoints and, like ICOS, to the B7-CD28 superfamily.

Literature: Hantschke M et al. (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.