Synonym(s)
death receptor; FasL; Fas-Ligand
DefinitionThis section has been translated automatically.
cells: activated T cells, NK cells
Structure: Membrane protein (40 kDa)
Note: CD 178 (also Fas ligand) belongs to the tumor necrosis factors. The binding of CD 178 to its receptor CD 95 (Fas or FasR) induces apoptosis. This mechanism plays a pathogenetic role in toxic epidermolysis, e.g. in Stevens-Johnson syndrome (see special comments on Fas ligand).
Application: FACS, IHC (P)
Note(s)This section has been translated automatically.
The soluble FAS ligand is also found in elevated concentrations in the serum of patients with severe drug reactions (see below Stevens-Johnson syndrome)
LiteratureThis section has been translated automatically.
- Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.
Prof. Dr. med. Peter Altmeyer