Cd16

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 03.04.2022

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Synonym(s)

FcgRIII; FcRIIIA; FcRIIIB

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DefinitionThis section has been translated automatically.

Marker for: NK cells, macrophages, neutrophil granulocytes.

Note: CD 16 designates two surface proteins from the group of Fc receptors:

(see also below) Cluster of differentiation

Note(s)This section has been translated automatically.

The receptor protein CD 16 is encoded by the FCGR3A gene. The FCGR3A gene is located on chromosome 1q23.3 and encodes CD16. Antigen-antibody complexes are cleared from the bloodstream via this receptor for the Fc portion of immunoglobulin G. The receptor protein binds to antigen-antibody complexes. The receptor protein binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Furthermore, the receptor protein is involved in antibody-dependent cellular-mediated cytotoxicity and antibody-dependent enhancement of viral infections.

LiteratureThis section has been translated automatically.

  1. de Vries et al.(1996) Identification of an unusual Fc-gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections. Blood 88: 3022-3027.
  2. Grier JT et al (2012) Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. J Clin Invest 122: 3769-3780.
  3. Liu B et al (2019) Polymorphism of FCGR3A gene in chronic beryllium disease. Genes Immun 20: 493-499.

Authors

Last updated on: 03.04.2022

Author: Prof. Dr. med. Peter Altmeyer