Cd158k

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 26.02.2021

Dieser Artikel auf Deutsch

Synonym(s)

KIR3DL2

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Acronym for "Cluster if differentiation 158k". CD 158k (syn. KIR3DL2) is a member of the Ig-like recptor family of natural killer cells (NK cells). In general, CD 158k is expressed only in a small number of NK cells and on rare cytotoxic (CD8+) T cells. CD158k is expressed relatively consistently on Sézary cells (important diagnostic crierium) and functions as a co-inhibitory receptor that increases resistance to activation-induced cell death(apoptosis). Antibodies against CD158k may represent a therapeutic option.

CD158k further serves as a receptor for CpG oligodeoxynucleotides (CpG-ODN). Activation by CpG-ODN leads to dephosphorylation of the transcription factor STAT3 and subsequent apoptosis.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.

Authors

Last updated on: 26.02.2021

Author: Prof. Dr. med. Peter Altmeyer