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Sézary cells

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Lutzner cells

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DefinitionThis section has been translated automatically.

Atypical lymphocytoid cells with T-cell markers.

OccurrenceThis section has been translated automatically.

Among others, it occurs in cutaneous T-cell lymphoma, mycosis fungoides, lupus erythematosus, lichen planus, psoriasis, unspecific chronic dermatitis and in arthritis with synovial secretion.

HistologyThis section has been translated automatically.

  • Cells with a large, indented core of 6-10 μm size.
  • Electron microscopy: Cerebriform nucleus, glycogen granules in the cytoplasm.
  • Blood smear: PAS positive.
  • Immunohistology: CD158k is expressed relatively constantly on Sezary cells (important diagnostic crystium) and acts as a co-inhibitory receptor which increases resistance to activation-induced cell death (apoptosis). Antibodies against CD158k may represent a therapeutic option.
  • CD164 and FCRL3 serve as further diagnostic markers.

Note(s)This section has been translated automatically.

CD26 is discussed as a specific marker for Sézary cells.

LiteratureThis section has been translated automatically.

  1. Fierro MT et al (2006) Expression pattern of chemokine receptors and chemokine release in inflammatory erythroderma and Sezary syndrome. Dermatology 213: 284-292

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer