Benzyl benzoate

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Benzyl benzoate; INCI designation: benzyl benzoate

Definition
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Ester derivative of benzoic acid belonging to the antiparasitosa. Benzyl benzoate is a respiratory poison for parasites and is particularly effective against scabies. It is also effective against lice and can be used as a repellent .

Indication
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Skabies, for training in repellents. Also possible with demodex folliculitis. Also used as a fragrance.

Dosage and method of use
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  • For skabies 10% (children up to 3 years) and 25% (children > 3 years, adults) in emulsions such as benzyl benzoate emulsion 10% or 25% (NRF 11.64.) for external use: On 3 consecutive days in the morning and evening, rub in the whole integument except the head and on the 4th day take a full bath and change bedding and clothing.
  • 5% as a foam for the treatment of mattresses, upholstered furniture and textiles, allow to dry and vacuum after 1 week.
  • 5% as a moist powder for the treatment of carpets, vacuum it off after 1-3 hours.

Undesirable effects
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Allergic reactions (component of Peru balsam!), seizures or gasping syndrome (if inadvertently taken or used with infusion systems purified with benzyl alcohol), conjunctivitis

Contraindication
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Pregnancy, lactation (application in the breast area), children < 3 years (risk of gasping syndrome: acidosis, CNS damage, respiratory depression, intracranial haemorrhages, hyperbilirubinaemia, leukopenia, thrombopenia, liver damage, purpura, death).

Preparations
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Antiscabiosum, Acarosan

Note(s)
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Remember! The use of benzyl benzoate is forbidden for newborns in the USA (deaths due to use of infusion systems purified with benzyl alcohol (so-called gasping syndrome = progressive encephalopathy, metabolic acidosis, bone marrow depression)!

Literature
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  1. Panahi Y et al (2015) The efficacy of topical and oral ivermectin in the treatment of human scabies. Ann Parasitol 61:11-16
  2. Werbrouck J et al (2015) C12-15 alkyl benzoate: a new cosmetic allergen? Contact dermatitis. doi: 10.1111/cod.12419

Outgoing links (3)

Antiparasitosa; Repellent; Skabies;

Authors

Last updated on: 29.10.2020