Basal cell carcinoma nodular - Altmeyers Encyclopedia

Synonym(s)

Basal cell carcinoma nodular; nodular basal cell carcinoma

Definition
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Most common basal cell carcinoma (about 60% of the basal cell carcinomas that occur), characterised by nodular, exophytic growth with a tendency towards central ulceration.

Localization
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Almost exclusively on the head, especially the zygomatic arch, bridge of the nose, inner corner of the eye, auricle, capillitium.

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Clinical features
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Initially small, skin-coloured, waxy, shiny, coarse, painless nodule with fine telangiectasias covering the edge of the nodule. Slow growth, possibly formation of several aggregated nodules. Central depression and atrophy, finally ulceration. Development of an ulcer with a (pearly) marginal wall consisting of shiny papules, so-called ulcus rodens.
Some nodular BCCs have irregular pigmentation, whereby the pigment (melanin) can be brown or blue (depending on the location of the pigment accumulation, see also Basal cell carcinoma, pigmented).

Histology
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S.u. Basal cell carcinoma, solid.

Differential diagnosis
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melanocytic nevus; sebaceous gland hyperplasia

Therapy
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S.u. Basal cell carcinoma.

Literature
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Mc Cormack et al (1997) Differences in ages and body site distribution of the histological subtypes of basal cell carcinoma. Arch Dermatol 133: 593-596
Peris K et al (2005) Imiquimod treatment of superficial and nodular basal cell carcinoma: 12-week open-label trial. Dermatol Surgery 31: 318-323