Angiomyxoma cutaneous D23.-

Rare, benign, dermal or subcutaneous new formation(s) consisting of mucus tissue, which can occur solitary or multiple times.

Cutaneous angiomyxomas usually occur monotopically as harmless neoplasms in the skin.

Cutaneous myxomas can be partial symptoms of syndromic entities (see below NAME syndrome or LAMB or Carney syndrome - cardiac and cutaneous myxomas, pigment disorders, neuroendocrine tumors).

Unclear, discussed are dominant inheritance, excessive production of acidic mucopolysaccharides of fibroblasts of unclear genesis and persistence of embryonic connective tissue.

Occurs more frequently between the 2nd and 3rd decade of life, with extracutaneous localisation preferably between the 6th and 7th decade of life.

extremities, neck and neck, genitals

Papular or nodular, flat, completely asymptomatic, soft, gentle protrusions of unchanged or slightly reddened skin. From time to time discharge of a stringy mucus possible. The changes develop very slowly and are perceived more as cosmetic disturbances than as "disease".

The (systemic) myxomas occurring in NAME syndrome are localized acrally on the skin (see below NAME syndrome).

A tumour localised in the dermis and subcutis, usually multilobular, clearly demarcated from the surrounding tissue, but not encapsulated. Spindly or star-shaped, reticularly connected cells are found. Storage of gelatinous substances in the meshwork, ectatic vessels. S.a.u. Myxoma cavernosum. Capillary vessel sections of varying density.

Fibroma molle: Solitary or more commonly multiple, approximately 0.1-0.5 cm (or larger), skin-colored, red or red-brown, soft skin polyps, usually narrow-based on the skin. They consist of connective tissue with variable epidermal, melanocytic, vascular or lipogenic involvement. If the surface is more keratinized (e.g. in case of permanent mechanical irritation), these fibromas are called "fibrokeratoma Unna". mostly smaller, protuberant, soft, skin-colored, multinodular tumors

Lipoma: slow-growing, soft to firm well-demarcated, subcutaneous, skin-colored growth. Often occurring in plural forms.

Acral persistent papular mucinosis: Rare, papular mucinosis considered a topographically distinct special form of localized lichen myxoedematosus. The disease is characterized by mostly symmetrical, asymptomatic (only occasionally mild itching is reported), ivory to skin-colored, 0.2-0.5 cm papules, especially on the backs of the hands and the extensor forearms.

The propensity for malignant degeneration is assessed differently; myxomas tend to recur.

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2. Allen PW et al (1988) Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients. Am J Surg Pathol 12: 519-530.
3. Calikoglu E et al (2002) Hyaluronate accumulation and decreased CD44 expression in perifollicular solitary cutaneous myxoma. Dermatology 205: 122-126
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