DefinitionThis section has been translated automatically.
Heterogeneous group of tumors that originate from the apocrine glandular epithelium. The majority of tumors are benign. With the few sweat gland carcinomas, the assignment apocrine / eccrine is often not possible. Admittedly, it also has no clinical relevance. Adnexal tumours with apocrine differentiation show an extraordinarily large histological variability with a rather monomorphic and uncharacteristic clinical picture, which often makes their exact classification difficult. In addition, there are difficulties due to the different nomenclature. The diagnosis "adnexal tumor with apocrine differentiation" is generally a histological random diagnosis. A useful histological phenomenon for apocrine secretion is the so-called decapitation secretion. Immunohistological markers for differentiation of apocrine secretion are: GCDFP-15 (gross cystic disease fluid protein), lysozyme and LeuM1.
ClassificationThis section has been translated automatically.
The classification presented here is essentially based on the morphological criteria developed on the HE section.
- Benign apocrine adnexal tumors:
- Adenoma, apocrine
- Accessory nipple
- Adenoma, ceruminous (ceruminoma)
- hidradenoma papilliferum
- Breast adenoma
- Poroma (see explanations for eccrine poroma)
- mixed tumour of the skin
- Syringocystadenoma papilliferum.
- Malignant apocrine adnexal tumors:
LiteratureThis section has been translated automatically.
- Castelli E et al (2002) Extramammary Paget Disease of the Axilla Associated With Comedo-like Apocrine Carcinoma In Situ. At J Dermatopathol 24: 351-357
- Kamiya H et al (2001) Apocrine poroma: review of the literature and case report. J cutan Pathol 28: 101-104
- Kuan SF et al (2001) Differential expression of mucin genes in mammary and extramammary Paget's disease. Am J Surg Pathol 25: 1469-1477
- Leonard N et al (2001) Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours. J Clin Pathol 54: 689-692
- Mahalingam M, Byers HR (2000) Intra-epidermal and intra-dermal sebocrine adenoma with cystic degeneration and hemorrhage. J Cutan cathode 27: 472-475
- Rudolph P (2002) Benign adnexal skin tumors. Pathologist 23: 71-78
- Usmani AS et al (2002) Trichoblastic neoplasm with apocrine differentiation. At J Dermatopathol 24: 358-360
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Incoming links (7)
Adenocarcinomas, apocrine; Adnextumors of the skin (overview); Biker's nodules; Breast adenoma; Carcinomas of the sweat glands; Mixed tumour of the skin; Syringocystadenoma papilliferum;Outgoing links (12)
Adenoma aggressive digital papillary; Adenoma, apocrine; Adenoma ceruminous; Apocrine sweat gland carcinoma; Breast adenoma; Hidradenoma papilliferum; Microcystic adnexal carcinoma; Mixed tumour of the skin; Nipple accessory; Paget's disease extramammary; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer