Methacholine provocation test

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 30.05.2022

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DefinitionThis section has been translated automatically.

Bronchoprovocation with methacholine to determine the one-second capacity (FEV1) (see provocation test)

IndicationThis section has been translated automatically.

Bronchial asthma, pollinosis, dust mite allergy.

ImplementationThis section has been translated automatically.

  • Inhalation of smallest amounts of methacholine in ascending doses.
  • After each inhalation, complete lung function measurement (recording of lung volume by spirometry).
  • A drop in forced one-second capacity (FEV1) of at least 20% allows estimation of the severity of bronchial hyperreactivity.
  • If bronchial constriction has occurred, application of a bronchodilator spray for inhalation. This makes it possible to classify the severity of the bronchial hypersensitivity.

LiteratureThis section has been translated automatically.

  1. Marogna M et al (2007) Long-lasting effects of sublingual immunotherapy for house dust mites in allergic rhinitis with bronchial hyperreactivity: A long-term (13-year) retrospective study in real life. Int Arch Allergy Immunol 142: 70-78

Authors

Last updated on: 30.05.2022

Author: Prof. Dr. med. Peter Altmeyer