Mercury ii-amide chloride

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

ammoniated mercury

Definition
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Water-insoluble compound closely related but not synonymous with mercury chloride. Component of eye and nose ointments. Relatively low irritation potential compared to mercury chloride.

General information
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  • In the current list of ingredients of the approved drugs, the substance appears. Its use as a component of prescriptions is also of historical significance and according to the current list of NRF prescriptions, it is no longer in use. The use of mercury(II) amide chloride as a substance in the standard block (preparation 1% in vaseline) is explained by its relatively low irritation potential compared to mercury chloride and the generally accepted indicator function for a group allergy to inorganic mercury compounds.
  • If sensitisation to amalgam is suspected, additional testing of mercury II-amide chloride is recommended. Cross-reactions between inorganic and organic mercury compounds are possible, but not obligatory. If sensitisation to organic mercury compounds, such as thiomersal, is suspected, they should therefore also be tested.
  • Closed occupational fields in case of sensitisation to mercury compounds (see thiomersal below): Dentistry (contact with metallic mercury; occupational sensitisation possible). However, the occupational field is not necessarily closed, as allergic contact reactions can usually be avoided by taking appropriate protective measures.
  • The further use of mercury and its compounds in industrial areas can therefore not be safely excluded, but apparently not an allergological problem from which specifically closed work opportunities can be derived.
  • Sensitisation to mercury(II) amide chloride has no effect on the ability to work in the general labour market. Taking into account the indicator function of this substance for sensitisation to mercury compounds, the effects are negligible, since the entire substance group is only marginally distributed on the general labour market in a disease-causing, unavoidable form.

Literature
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  1. Becker D, Dickel H, Geier J, John SM, Leesmann H, Mahler V, Rogosky E, Skudlik C, Wagner E, Weisshaar E, Diepgen TL, for the working group "Evaluation of allergens at BK 5101" of the Working Group for Occupational and Environmental Dermatology in the German Dermatological Society (2008) MdE-evaluation for mercury(II)-amide chloride. Evaluation of the reduction in earning capacity for mercury(II) amide chloride]. Dermatol Occupation Environment 56: 63-65

Outgoing links (1)

Thiomersal;

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Last updated on: 29.10.2020