CCR1

CCR1, or C-C chemokine receptor type 1, is a receptor protein encoded by the CCR1 gene in humans. CCR1 is a member of the beta-chemokine receptor family, which belongs to the G-protein-coupled, transmembrane chemokine receptors. The CCR1 gene encoding CCR1 is associated with a family of genes including CCR2, CCRL2, CCR3, CCR5 and CXCR1 located on chromosome 3p.

The CCR1 receptor is expressed by different cells in different densities, such as neutrophil and eosinophil granulocytes, monocytes, T cells, osteoclasts.

The activity of the receptor influences inflammatory reactions via leukocyte chemotaxis and via a balance of cytokine interactions.

The ligands that bind to this receptor are the chemokines CCL3 (also MIP-1 alpha), CCL5 (also RANTES), CCL7 (also MCP-3), CCL9 and CCL23 (also MPIF-1).

CCR1 antagonists could play a role in rheumatoid arthritis (M06.99) and other autoimmunological diseases and in the treatment of bone lesions in multiple myeloma (C90.00). They have not yet achieved clinical significance.

CCR1 "knock-out studies" have demonstrated an important role of the CCR1 receptor in inflammatory responses to viral and parasitic infections.

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2. Zimmermann HW et al (2014) CCR1 and CCR2 antagonists. Curr Top Med Chem 14:1539-1552.
3. Vallet S et al (2011) CCR1 as a target for multiple myeloma. Expert Opinion Ther Targets 15:1037-1047.