Her1 Bilder

Schjematic representation of the different receptor types that play a role in tumor therapeutics. Receptor activation leads to recetpordmierization, to phosphorylation of the intracellular domain and to activation of the "down stream" switched signal cascade with impulses from proliferation and anti-apoptosis.

Schematic representation of an activation of the EGF-receptor, in this case binding of the ligand to ErB-3 which dimerizes with HER2/neu. hertologous dimerization leads to a now active dimeric receptor complex which causes subsequent biochemical reactions (phosophorylation).