Vasculitis, hepatitis c-associated D69; D89.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Vasculitis following infection with the hepatitis C virus

Clinical features
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Arthralgias, septic fever attacks, neurological symptoms, glomerulonephritis, possibly erysipelas skin changes.

Laboratory
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Increase of SPA and CRP, detection of circulating immune complexes. Frequent increase of cryoglobulins (see also vasculitis with essential cryoglobulinemia).

Histology
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Vasculitis of the small vessels of the upper corium accompanied by hyaline thrombi.

Therapy
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Low-dose steroids, cytostatics and HCV therapy in accordance with guidelines.

Literature
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  1. Lamprecht P et al (1998) Hepatitis C virus-associated cryoglobulinemic vasculitis. Physiopathology, diagnosis and therapy. Dtsch Med Weekly 123: 637-642
  2. Lamprecht P et al (2001) Immunological and clinical follow up of hepatitis C virus associated cryoglobulinaemic vasculitis. Ann Rheum Dis 60: 385-390
  3. Mendez P et al (2001) Hepatitis C, cryoglobulinemia, and cutaneous vasculitis associated with unusual and serious manifestations. Am J Gastroenterol 96: 2489-2493
  4. Nakajima A et al (2003) Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection. Internal Med 42: 1042-1046

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Last updated on: 29.10.2020