Urokinase (overview)

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Urokinase is an activator of plasminogen isolated from human urine and kidney cells and is measurable in plasma.

General informationThis section has been translated automatically.

Urokinase is detectable in many tissues, especially in kidney cells, but also in tumours. It is a single-chain proenzyme with a molecular weight of 24,000 D (scu-PA). During its activation, the urokinase is converted into a two-chain molecule (tcu-PA), whereby the single chains are connected to each other by a single disulphide and thus activate the plasminogen in the plasma. The resulting plasmin activates the scu-PA (single chain urokinase-type plasminogen activator) to tcu-PA (two-chain urokinase plasminogen activator).

LiteratureThis section has been translated automatically.

  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 105f.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer