Urokinase (overview)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Urokinase is an activator of plasminogen isolated from human urine and kidney cells and is measurable in plasma.

General information
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Urokinase is detectable in many tissues, especially in kidney cells, but also in tumours. It is a single-chain proenzyme with a molecular weight of 24,000 D (scu-PA). During its activation, the urokinase is converted into a two-chain molecule (tcu-PA), whereby the single chains are connected to each other by a single disulphide and thus activate the plasminogen in the plasma. The resulting plasmin activates the scu-PA (single chain urokinase-type plasminogen activator) to tcu-PA (two-chain urokinase plasminogen activator).

Literature
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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin S. 105f.

Incoming links (3)

Aprotinin; SERPINE1 gene; Vitronectin;

Outgoing links (2)

Plasmin; Plasminogen;

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Last updated on: 29.10.2020