Ticlopidine

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Antiplatelets.

Half-lifeThis section has been translated automatically.

30–50 h

IndicationThis section has been translated automatically.

Prophylaxis of arterial and venous thromboses, arterial occlusive disease of the peripheral type.

Limited indicationThis section has been translated automatically.

Severe liver dysfunction.

Dosage and method of useThis section has been translated automatically.

1-3 times/day 250 mg p.o.

Remember! Ticlopidine should not be administered to patients with increased bleeding tendency or gastrointestinal ulcers. The preparation should be discontinued 1 week before planned operations. In emergencies the effect of Ticlopidine can be reversed by a single administration of 20 mg methylprednisolone. Before the start of therapy and during the first 3 months of treatment, a differential BB and platelet count is required at 14-day intervals!

Undesirable effectsThis section has been translated automatically.

Nausea, abdominal pain, diarrhea, allergic reactions, BB changes, jaundice with hepatitis and cholestasis, headache and dizziness.

InteractionsThis section has been translated automatically.

See Table 1.

ContraindicationThis section has been translated automatically.

Pregnancy, lactation, agranulocytosis, bleeding tendency also in the medical history, chronic inflammatory bowel diseases, children and adolescents < 16 years, leukopenia, gastrointestinal ulcers, neutropenia, operations, acute hemorrhagic apoplexy, thrombopenia.

PreparationsThis section has been translated automatically.

Tiklyd

PatientinformationThis section has been translated automatically.

Remember! The patient should consult the doctor immediately if ulcers appear in the mouth and throat area, tonsillitis and fever. Ticlopidine should be taken after meals to reduce the gastrointestinal side effects!

TablesThis section has been translated automatically.

Significant interactions of ticlopidine

Antirheumatic drugs, non-steroidal	Bleeding tendency ↑
Cephalosporins	Bleeding tendency ↑
Cimetidine	Ticlopidine levels ↑
Clozapine	Agranulocytosis, avoid combination
Coumarins	Bleeding tendency ↑
Dihydroergotamine	Bleeding tendency ↑
Penicillin i.v.	Bleeding tendency ↑
Theophyllins	Theophylline levels ↑
Platelet concentrates	Ticlopidine effect ↓

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer