Polyätiological, microangiopathic, mostly small spotted purpura (petechiae) caused by thrombocytopenia of varying aetiology and severity.
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Purpura thrombocytopenicM31.1
DefinitionThis section has been translated automatically.
EtiopathogenesisThis section has been translated automatically.
The causes of thrombocytopenia include:
- educational disorders:
- Diminished megakaryocytopoiesis:
- Congenital
- Acquired: E.g. by drugs, radiotherapy, chemicals, viruses, bacterial infections.
- Displacement: E.g. by bone marrow carcinosis, leukemia, malignant lymphomas (e.g. plasmocytoma), osteomyelofibrosis.
- Ineffective thrombocytopoiesis: e.g. Wiskott-Aldrich syndrome.
- Diminished megakaryocytopoiesis:
- Increased degradation or consumption:
- Immunological:
- Primary autoantibody formation: e.g. idiopathic thrombocytopenic purpura.
- Secondary autoantibody production: e.g. drugs, collagenosis, immune complex diseases, antiphospholipid antibody syndrome).
- Non-immunological:
- E.g. disseminated intravascular coagulation.
- Immunological:
- distribution disorders:
- E.g. platelet pooling in the spleen for splenomegaly.
Clinical featuresThis section has been translated automatically.
Hemorrhages, ecchymoses, suggestions- Capillary damage is also common.
TherapyThis section has been translated automatically.
- Varies depending on the triggering cause.
- Avoid a triggering drug. Depending on the clinic and platelet count, systemic glucocorticoids are indicated, e.g. prednisone (e.g. Decortin) initial 100 mg/day, gradual reduction according to clinic.
- The treatment of thrombocytopenia is a treatment to be carried out under internal control.
Note(s)This section has been translated automatically.
The thrombocytopenic purpura is not to be confused with the Moschcowitz syndrome, the thrombotic-thrombocytopenic purpura.