Polyarteritis nodosa, systemic, multiple, chronically dynamic, since 2 years steadily increasing, progressive in size, localized on the extensor side of the lower leg, disseminated, 0.5-4.0 cm large, very painful, flatly elevated, red and brown plaques, nodules (iceberg phenomenon) as well as very painful ulcers.
Polyarteriitis nodosa, systemic. excisional biopsy from an infiltrated node reaching into the subcutaneous fatty tissue. in the tissue block on the right a medium caliber artery with thrombus.
Polyarteritis nodosa, systemic. Thrombosed vessel at the corium-subcutaneous junction.
Polyarteritis nodosa, systemic section of the above figure: Fresh thrombus in the vascular lumen, perivascularly localized edema with sparse inflammatory infiltrates.
Polyarteriitis nodosa, systemic. further detail: Medium caliber artery with fresh central thrombus; the vessel wall is loosened with sparse inflammatory infiltrates of lymphocytes and neutrophil granulocytes.
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