Synonym(s)
angiokeratoma acroasphycticum digitorum; Mibelli type angiokeratosis; Mibell's disease
HistoryThis section has been translated automatically.
Cottle, 1879; Mibelli, 1889
DefinitionThis section has been translated automatically.
Rare, autosomal-dominant, gynecotropic hereditary disease characterized by acrally localized multiple angiokeratomas.
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ManifestationThis section has been translated automatically.
First occurrence often during puberty; mainly in vagotonic patients with cold intolerance and tendency to acrocyanosis and frostbite.
LocalizationThis section has been translated automatically.
Acral preference; especially fingers and toes, also elbows and knees.
Clinical featuresThis section has been translated automatically.
Mostly symmetrically arranged, at first flat, pinhead to lenticular erythema, later on blue-red papules with rough, sometimes also woolly surface.
HistologyThis section has been translated automatically.
Circumscribed cavernous extensions of capillary loops, acanthotic, hyperkeratotic epidermis.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
If necessary, diathermy, laser treatment or excision if desired.
LiteratureThis section has been translated automatically.
- Cottle W (1879) Warty growths. St. Georges Hospital Reports 9: 753-762
- L'angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 26: 159-180 and 260-276
- Mibelli V (1889) Di una nuova forma di cheratosi angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 30: 285-301
- Sommer S et al (2001) Severe predominantly acral variant of angiokeratoma of Mibelli: response to long-pulse Nd:YAG (1064 nm) laser treatment. J Am Acad Dermatol 45: 764-766
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Incoming links (4)
Angiokeratoma acroasphycticum digitorum; Angiokeratomas, acral pseudolymphomatous childhood; Fabry's disease; Mibell's disease;Outgoing links (8)
Acanthosis; Angiokeratoma circumscriptum; Angiokeratomas (overview); Excision; Fabry's disease; Laser; Papel; Perniones;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer