Synonym(s)
Heparin induced platelet activation assay; Heparin-induced platelet activation test; HIPA
DefinitionThis section has been translated automatically.
HIPAA is the acronym for "heparin induced platelet activation assay". This test detects HIT antibodies against various antigens. However, only IgG class antibodies are detected.
In this test washed platelets from healthy donors are incubated with the patient's serum and low (0.2IU/ml) and high (100IU/ml) heparin concentrations.
General informationThis section has been translated automatically.
Platelet activation at low but not high heparin concentrations is typical for HIT. Activation is measured as the release of radioactive serotonin (serotonin release test), oider visually (HIPA test).
LiteratureThis section has been translated automatically.
- Greinacher T (2008) Thrombocytopenia and platelet dysfunction. In: Thomas L (Ed) Laboratory and diagnosis. Th-Books Publishing Company Ltd, Frankfurt/Main p. 918
Prof. Dr. med. Peter Altmeyer