Synonym(s)
Fibrin stabilizing factor; Laki Lorand Factor
DefinitionThis section has been translated automatically.
Factor XIII a is an enzyme and as a coagulation factor it is an important part of the blood coagulation cascade. Factor XIIIa consists of 2x 2 subunits, 2x A and 2x B. Physiological concentration in blood plasma: 10 μg/ml; half-life 5-9 days.
The subunits A and B of factor XIII are encoded by two different genes:
For A: gene 6p25-p24; for B: gene 1q31-q32.1
Immunohistochemically, factor XIIIa reacts with fibrocytes, e.g. in dermatofibromas and the fibrous nasal papule. Dermatofbrosarcoma protuberans reacts CD34+ but negatively for factor XIIIa.
LiteratureThis section has been translated automatically.
- West KL et al (2014) Immunohistochemical markers in fibrohistiocytic lesions: factor XIIIa, CD34, S-100 and p75. At J Dermatopathol 36:414-419
Prof. Dr. med. Peter Altmeyer