Factor vii

Factor VII is a coenzyme that activates the extrinsic system with factor III. It is an enzyme chain glycoprotein with a molecular weight of 48,000 - 100,00 D depending on the type of tissue from which it is extracted. In electrophoresis, F-VII migrates in the alpha2 or beta fraction. The serum concentration is 3 mg/dl. The half-life is four to six hours.

F-VII binds to the platelet surface. Together with F-III, phospholipids, platelet factors and calcium ions, factor VII activates factor X and, to a lesser extent, factor IX. The synthesis of F-VII is vitamin K-dependent. The detection is carried out by ELISA.

The factor VII was discovered by Owren, the importance of the F-VII was analysed by Alexander. The F-VII is activated by the tissue factor (F-III).

1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 58.