DefinitionThis section has been translated automatically.
Factor IV, the calcium ions, is essential for the activation of factor VIIa and acts as a cofactor in complex IXa, VIIIa and phospholipids, among other things. Ca++ also acts as an essential cofactor in complex Xa, factor V and phospholipids.
General informationThis section has been translated automatically.
The importance of calcium for coagulation was discovered in the nineties of the 19th century by the Frenchman Maurice Arthus (1862-1945). Maurice Arthus could prove that the addition of oxalates or fluorides prevented the coagulation process, on the other hand he proved that the addition of calcium restored the coagulation process.
LiteratureThis section has been translated automatically.
- HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 56.
Prof. Dr. med. Peter Altmeyer