Synonym(s)
DefinitionThis section has been translated automatically.
Danaparoid sodium (mixture of low molecular weight sulphated glycosaminoglycans - dermatan, chondrotin and heparan sulphate - from animal intestinal mucosa). Selective factor Xa inhibitor. Danaparoid shows no cross-reaction to heparin-associated antibodies and is therefore the drug of choice in patients with HIT-2.
Half-lifeThis section has been translated automatically.
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IndicationThis section has been translated automatically.
Thrombosis prophylaxis in patients with heparin-associated thrombopenia and after allergic reactions to systemic heparins (see heparin-induced thrombocytopenia).
Dosage and method of useThis section has been translated automatically.
Prophylaxis of deep vein thrombosis: 2 times/day 750 IU/day s.c; for the treatment of HIT-2: intial 2500 IU. i.v. At KG < 55kg 1250 IU., at > 90 kg 3750 IU., then 400 IU/h over 3 hours. Maintenance dose: 150-200 IU/h. Contraindication in renal and hepatic failure.
Remember! No i.m. application!
PreparationsThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Greinacher A et al (2003) Heparin-induced thrombocytopenia. Dtsch Ärztebl 100: 2220-2229
- HA Neumann (2014) The coagulation system. ABW-Scientific Publisher GmbH Berlin
Prof. Dr. med. Peter Altmeyer