Vitexin

Secondary plant substance, which as a glycolised flavone belongs chemically to the group of flavones (yellow dyes).

Vitexin is found in many plants, mostly in beta-glycosidic compounds (see glycosides below) such as Passiflora incarnata(passion flower), Crategus species, Viola tricolor, in the seeds of fenugreek (Trigonella foenum-graecum) and others.

The effects of Vitexin are described as anti-inflammatory, antioxidant, cardioprotective and neuroprotective. The results are based on experimental studies.

1. Bhardwaj M et al (2015) Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. Life Sci 142:36-48.
2. Chen L et al (2016) Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. Mol Med Rep 14:5607 5613.
3. He M et al (2016) A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia 115:74-85.
4. Rosa SI et al (2016) Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. Phytomedicine 23:9-17.