Solanum nigrum

Herbaceous nightshade plant(Solanum), up to 70 cm high with dark green leaves and white
flowers, similar in appearance to the potato plant (Solanum tuberosum). Black, round, shiny, pea-sized berries containing the seeds. Flowering time: June to October, fruit ripening: September to October.

Parent plant of Herba Solani nigri (nightshade herb), whose extracts are used systemically and externally for medicinal purposes.

Medical applications:

• Systemic: Various studies have shown that extracts of Solanum nigrum have a suppressive effect on various diseases. tumor cell lines and hepatoprotective. Furthermore, they increase the cytotoxicity of various tumor cell lines. Cytostatics (Cisplatin, Doxyrubicin and others)
• External: Extracts are used for eye inflammation, as compresses for acute inflammation of the skin.
  

Steroid alkaloids solanine, solasonine and solamargine. It also contains saponins and various tannins.

1. Lai YJ et al. (2016) Anti-Cancer Activity of Solanum nigrum (AESN) through Suppression of Mitochondrial Function and Epithelial-Mesenchymal Transition (EMT) in Breast Cancer Cells. Molecules 21. pii: E553.
2. Liu FP et al. (2016) Hepatoprotective effects of Solanum nigrum against ethanol-induced injury in primary hepatocytes and mice with analysis of glutathione S-transferase A1. J Chin Med Assoc 79:65-71.
3. Nguta JM et al. (2016) Antimycobacterial and cytotoxic activity of selected medicinal plant extracts. J Ethnopharmacol 182:10-15.
4. Razali FN et al.(2016) Tumor suppression effect of Solanum nigrum polysaccharide fraction on Breast cancer via immunomodulation. Int J Biol Macromol 92:185-193.
5. Singh DP et al.(2015) Hepatoprotective Effect of A Polyherbal Extract Containing Andrographis Paniculata, Tinospora Cordifolia and Solanum Nigrum Against Paracetamol Induced Hepatotoxicity. Pharmacogn Mag 11(Suppl 3):375-379.
6. Tai CJ et al. (2013) Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evid Based Complement Alternat Med doi: 10.1155/2013/514719
7. Wang CW et al.(2015) Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells. Integr Cancer Ther 14:546-555.
8. https://www.awl.ch/heilpflanzen/solanum_nigrum/schwarzer-nachtschatten.htm

9. Montag A (2023) Plants and skin. Springer-Verlag GmbH. P. 747-748
   https://doi.org/10.1007/978-3-662-63014-3_7