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Rosemary acid

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

2-O-Caffeoyl-2-hydroxy-2,3-dihydrocoffee acid; CAS No: 20283-92-5; rosmarinic acid (engl.)

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DefinitionThis section has been translated automatically.

Rosemary acid is the trivial name of a secondary plant substance widely used in the plant kingdom, which is chemically the ester of caffeic acid (compound with 3-(3,4-dihydroxyphenyl)-lactic acid). Plants apparently synthesize rosemary acid as a defense against fungi and bacteria. It also protects the plant against predators.

OccurrenceThis section has been translated automatically.

Especially the families of Lamiaceae contain a lot of rosemary acid. Rosemary acid is also found in ferns and hornworts.

EffectsThis section has been translated automatically.

Rosemary acid has antiviral, antibacterial and anti-inflammatory and potent antioxidant and cardioprotective properties. The positive results of a 0.3% rosemary acid ointment for atopic eczema described in a smaller study require further confirmation. It is one of the active ingredients of Rosmarini folium, rosemary leaves and Melissae folium (balm leaves).

Pure rosemary acid has antioxidant and antitumour properties. It can be easily absorbed through the skin (evidence from animal experiments).

Rosemary acid, like many other phenol carboxylic acid esters, has tanning properties (also known as lamiacea tanning agent).

Field of application/useThis section has been translated automatically.

In different. Melissa preparations with antiheptic indication (e.g. Lomaherpan® cream); also in ointments for sports injuries (e.g. Traumaplant®); furthermore in phytotherapeutics for acute urinary tract infections and dysuric complaints (combination preparations of lovage roots, rosemary leaves, centaury - e.g. Canephron®).

LiteratureThis section has been translated automatically.

  1. al-Sereiti MR et al.(1999) Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials Indian J Exp Biol 37:124-130.
  2. Amoah SK et al (2016) Rosemary Acid-Pharmaceutical and Clinical Aspects. Planta Med 82:388-406.
  3. Ferreira LG et al (2013) Is rosmarinic acid underestimated as an experimental cardiovascular drug? Acta Cir Bras 28 Suppl 1:83-87.
  4. Lee J et al (2008) Effect of rosmarinic acid on atopic dermatitis. J Dermatol 35:768-771.
  5. Moore J et al (2016) Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols. Nutrients 17:8.
  6. Nabavi SF et al. (2015) The cellular protective effects of rosmarinic acid: from bench to bedside. Curr Neurovasc Res 12:98-105.
  7. Ritschel WA et al (1989) Percutaneous absorption of rosmarinic acid in the rat. In: Meth. Exp. Clin. Pharmacol 11: 345-353.
  8. Tong LX et al (2014) Nutrition: the future of melanoma prevention? J Am Acad Dermatol 71:151-160.

Authors

Last updated on: 29.10.2020

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Martina Bacharach-Buhles