Menthoxypropanediol

Menthoxypropanediol is a synthetic derivative of menthol. The substance has a 2.0-2.5 times stronger cooling effect than menthol.

Menthoxypropanediol is like the naturally occurring menthol a TRPM8 - agonist.

The family of cellular TRP ion channels is characterized by the fact that they have several transmembrane regions and are permeable to cations. One of these channels - TRPM8 (TRPM8 = transient receptor potential melastin 8, also called menthol receptor ) - is cooled by chemical coolants (including menthol itself as well as various other substances). menthol derivatives such as menthoxypropanediol). There is also evidence that activation of theTRPM8 receptor inhibits UV-induced inflammatory activities.

Furthermore, clinical studies in patients with atopic eczema have shown an antipruritic (and anti-eczematous) effect of menthoxypropanediol-containing topicals.

Contact allergies are described for the application of cosmetic external agents.

Eucerin® AtopiControl Acute Care

1. Franken L et al (2013) Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic. Contact dermatitis 69:377-378.
2. Roggenkamp D et al (2016) Menthoxypropanediol inhibits nerve growth factor-induced nerve fibre sprouting in coculture models of sensory neurons and skin cells. Exp Dermatol 25:824-826.
3. Angelova-Fischer I et al(2014) A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares. J Eur Acad Dermatol Venereol 28 Suppl 3: 9-15. https://www.ncbi.nlm.nih.gov/pubmed/24702445
4. Ständer S et al(2016) Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin. J Eur Acad Dermatol Venereol doi: 10.1111/jdv.14041.