Hypericum perforatum

Last updated on: 20.05.2025

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

see under St. John's wort

Trade namesThis section has been translated automatically.

Laif® 900 Filmtbl,

Arthrodynat® ointment, Bedan® cream, Bedan ® face cream, Befelka® oil, Buenoson® N ointment, Dolo-cyl® oil - muscle and joint oil, Jarsin® tbl 300-750, St. John's wort ratiopharm®, Kytta ointment®, Phönox Kalophön ointment, Rhoival® tea


Note(s)This section has been translated automatically.

St. John's wort has been shown to inhibit Cyp3A4 (see cytochrome P450 enzymes below). This leads to a slower degradation of its substrates (prolongation of efficacy). Phototoxic! Caution during the summer months, no UV exposure!

LiteratureThis section has been translated automatically.

  1. Apaydin EA et al.(2016) A systematic review of St. John's wort for major depressive disorder. Syst Rev 5:148.
  2. Becker LC et al. (2014) Amended safety assessment of Hypericum perforatum-derived ingredients as used in cosmetics. Int J Toxicol. 33(3 Suppl):5S-23S.
  3. Golsch S et al (1997) Reversible increase of photosensitivity in the UVB range by St. John's wort extract preparations. Dermatologist 48: 249-252
  4. Huang LF et al (2014) Hypericin: chemical synthesis and biosynthesis. Chin J Nat Med 12:81-88.
  5. Reichling J et al. (2003) St. John's Wort (Hypericum perforatum L.)--multicompound preparations versus single substances. Forsch Komplementarmed Klass Naturheilkd 10(Suppl1): 28-32.
  6. Saller R et al. (2003) St. John's Wort (Hypericum perforatum): a plurivalent raw material for traditional and modern therapies. Forsch Komplementarmed Klass Naturheilkd 10(Suppl1): 33-40.
  7. Schempp CM et al (2003) Randomised, placebo-controlled double-blind, half-site trial Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study. Dermatologist 54: 248-253
  8. Schulz V (2001) Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. Phytomedicine 8:152-160.
  9. Wölfle U et al (20149 Topical application of St. John's wort (Hypericum perforatum). Planta Med 80(2-3):109-120.
  10. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-hypericum-perforatum-l-herba-well-established-medicinal-use_en.pdf
  11. https://arzneipflanzenlexikon.info/johanniskraut.php.
  12. Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 134-135
  13. Hoffmann J ET AL. (2020) New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders. Biomedicines. 8, 27; doi:10.3390/biomedicines8020027.

Last updated on: 20.05.2025