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Furanocoumarins

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 20.05.2022

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Synonym(s)

furanocoumarins

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DefinitionThis section has been translated automatically.

Tricyclic ring systems, where the furan ring is either linear or angularly linked to the coumarinum

The linear 7,6 - furanocoumarins are called psoralenes. They are photosensitising on which the PUVA therapy with 8-methoxypsoralen is based (see PUVA).

The most important representatives of the angular 7,8-furanocoumarins are pimpinellin (see below Pimpinellae Radix) and angelicin, which can be found in Apiaceae species, in Rutaceae and Fabaceae. Also the highly toxic and carcinogenic mycotoxins found in certain moulds (especially Aspergillus flavus), the aflatoxins have furanocoumarin structures.

Note(s)This section has been translated automatically.

Recent studies indicate that the furanocoumarins contained in citrus may increase the risk of non-melanocytic skin cancer due to phototoxic/sensitizing effects associated with UV radiation.

LiteratureThis section has been translated automatically.

  1. Almutawa F et al (2013) Systematic review of UV-based therapy for psoriasis. Am J Clin Dermatol 14:87-109.
  2. Atzmony L et al (2016) Treatments for cutaneous lichen planus: A Systematic Review and Meta-Analysis. Am J Clin Dermatol 17:11-22.
  3. Zic JA (2015) Extracorporeal photopheresis in the treatment of mycosis fungoides and sézary syndrome. Dermatol Clin 33:765-776.
  4. Sakaki JR et al (2021) Citrus Consumption and the Risk of Non-Melanoma Skin Cancer in the Women's Health Initiative. Cancers (Basel). 30;:2173

Authors

Last updated on: 20.05.2022

Authors: Prof. Dr. med. Peter AltmeyerProf. Dr. med. Martina Bacharach-Buhles