Natural catechin derivative (polyphenol), which is contained in green tea, among other things. The medical application is as a local therapeutic agent for the therapy of condylomata acuminata in the genital and perianal area in adult immunocompetent patients. The local therapeutic agent contains a purified dry extract of green tea leaves (Camellia sinensis). The main component of the extract is epigallocatechin gallate. The extract also contains a large number of other catechins.
Images (2)
Epigallocatechin gallate
DefinitionThis section has been translated automatically.
IndicationThis section has been translated automatically.
Condylomata acuminata in immunocompetents.
Complication(s)This section has been translated automatically.
The recurrence rate after Veregen® treatment is 6.5%.
Dosage and method of useThis section has been translated automatically.
Veregen: Apply 3 times/day to the condylomas. Application in the vagina, urethra or anus should be avoided.
Undesirable effectsThis section has been translated automatically.
Slight local skin reactions.
PreparationsThis section has been translated automatically.
Veregen® 10 % Ointment
Note(s)This section has been translated automatically.
The approval of a 10 % ointment from green tea extract is based on two randomized double-blind placebo-controlled phase III trials (CT 1017 and CT 1018). A total of 608 immunocompetent adults with genital and perianal warts were included. Of these, 401 patients were treated with Veregen 10 % ointment, 207 patients with the drug-free ointment base until complete healing of the genital warts, but for a maximum of 16 weeks. The primary endpoint was the complete removal of all condylomas. In the verum group, complete healing occurred in 61 percent of the patients. This was the case in 44 percent of the placebo group. A reduction of warts by at least half was achieved in 76 percent of the patients in the veregen group and in 52 percent in the placebo group. Regarding recurrence rates, Veregen apparently performs better than podophyllotoxin, imiquimod or cryotherapy.
LiteratureThis section has been translated automatically.
- Yang Y et al (2016) Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats. Sci Rep 6:29546.
- Garcia FA et al (2014) Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. Gynecol Oncol 132:377-382.
- He L et al (2013) (-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α. Cancer chemother Pharmacol 71(:713-725.