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Colchici semen
Synonym(s)
DefinitionThis section has been translated automatically.
Semen colchici, the official preparations of the seeds of autumn crocus contains preparations of the dried and crushed seeds. Treatment with autumn crocus seeds can only be carried out if the preparations are adjusted to an exact amount of colchicine.
ESCOP monograph: no processing
HMPC monograph: no processing
Commission E monograph: positive evaluation for auten gouty attack; Familial Mediterranean fever.
IngredientsThis section has been translated automatically.
The active ingredients are around 20 different colchicine alkaloids with the main alkaloid colchicine. It also contains fatty oil, proteins and sugar.
EffectsThis section has been translated automatically.
According to Commission E: antichemotactic, antiphlogistic, mitosis-inhibiting. Folk use in rheumatic diseases; experimentally in autoimmunological diseases, locally in actinic keratoses.
Field of application/useThis section has been translated automatically.
Acute onset of gout, familial Mediterranean fever. Experimentally topical in actinic keratoses; furthermore in autoinflammatory syndromes like PAFA.
DosageThis section has been translated automatically.
In acute attacks of gout 1mg p.o. followed by repetitive doses (at 1-2 hourly intervals) of 0.5mg-1.0mg. A daily dose of 8.0mg must not be exceeded.
Undesirable effectsThis section has been translated automatically.
Diarrhoea, nausea, vomiting (see package insert of finished products)
ContraindicationThis section has been translated automatically.
Impaired kidney function, blood work. (e.g. anemia), known gastrointestinal diseases, reduced cardiovascular function, polymorbidity, liver disease, children, adolescents, pregnancy.
Trade namesThis section has been translated automatically.
Colchicum-Dispert® coated tablet
Note(s)This section has been translated automatically.
Colchicine is toxic. The lethal dose is about 20mg. Both drug and pure colchicine are prescription drugs.
LiteratureThis section has been translated automatically.
- Dustin P (1963. New aspects of the pharmacology of antimitotic agents. Pharmacol Rev15: 449-480.
- Faghihi G et al (2016) Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study. Adv Med doi: 10.1155/2016/5918393.
- Finkelstein Y et al(2010) Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila) 48: 407-414.
- Vanoni F et al (2016) PFAPA syndrome: a review on treatment and outcome. Pediatrics Rheumatol Online J 14:38.