The SQLE gene (SQLE stands for: squalene epoxidase) is a protein-coding gene. GO (Gene Ontology) annotations associated with this gene include oxidoreductase activity and squalene monooxygenase activity.
SQLE gene
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General informationThis section has been translated automatically.
The enzyme encoded by this gene, squalene monooxygenase (squalene epoxidase, SE), is the enzyme that catalyzes the oxidation of squalene to S-squalene-2,3-epoxide. Squalene epoxidase is a microsomal flavin monooxygenase that catalyzes the first step of oxygenation in cholesterol synthesis, namely the conversion of squalene to the non-sterol precursor for lanosterol, 2,3-(S)-monooxidosqualene (MOS), and is one of the rate-determining enzymes for cholesterol biosynthesis (Chen C et al.2023).
Recently, studies have reported that the SNP in the SQLE gene is associated with several meat quality traits, including backfat thickness, carcass weight, meat color (yellowness), fat composition, and water-holding capacity. Subsequently, inhibition of SQLE expression in preadipocytes was found to significantly inhibit adipogenesis . In addition, previous studies have demonstrated the link between SQLE and cholesterol metabolism and adipogenesis (Stopsack KH et al. 2016; Yang F et al. 2021; Xiong L et al. 2021).
Diseases associated with SQLE include tinea corporis and tinea cruris. Associated metabolic pathways include the super pathway of cholesterol biosynthesis and metabolism of steroids.
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The antimycotics terbinafine or amorolfine specifically inhibit squalene epoxidase in filamentous fungi. In this respect, they are used for trichophytia of the skin, e.g. to combat nail fungus (Uhrlass S et al. 2022)
LiteratureThis section has been translated automatically.
- Chen C et al. (2023) Novel Insight into the Role of Squalene Epoxidase (SQLE) Genes in Determining Milk Production Traits in Buffalo. Int J Mol Sci 24:2436.
- Stopsack KH et al. (2016) Cholesterol Metabolism and Prostate Cancer Lethality. Cancer Res 76: 4785-4790.
- Uhrlass S et al. (2022) Trichophyton indotineae-An Emerging Pathogen Causing Recalcitrant Dermatophytoses in India and Worldwide-A Multidimensional Perspective. J Fungi (Basel) 8:757.
- Yang F et al. (2021) MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation through SQLE. Front Cell Dev Biol 9: 655889.
- Xiong L et al. (2021) Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis. Front Cell Dev Biol 9: 653188.