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Fusaric acid

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

5-butylpicolinic acid; 5-Butylpyridine-2-carboxylic acid; 5-n-butylpicolinic acid; 5-n-butyl-pyridine-2-carboxylic acid; CAS number: 536-69-6; fusaric acid; Fusaric acid

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HistoryThis section has been translated automatically.

Teijiro Yabuta, 1934

DefinitionThis section has been translated automatically.

Mycotoxin (mould toxin) with the molecular formula: C10H13NO2. The mycogenic metabolic product is formed by the mould Fusarium heterosporum and belongs to the family of Fusarium toxins.

General informationThis section has been translated automatically.

Fusarin acid has an immunotoxic effect and leads to MAPK activation in mononuclear blood cells (Dhani S et al. 2017). It has an inhibitory effect on dopamine-beta-hydroxylase (enzyme that converts dopamine to norepinephrine), has an antihypertensive effect. Synergistic effects with other mycotoxins are possible, e.g. with deoxynivalenol (DON).

LiteratureThis section has been translated automatically.

  1. Dhani S et al (2017) Fusaric acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cells.Sci Rep7:3051

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer