Znf431 gene

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 14.04.2022

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Synonym(s)

KIAA1969; Zinc Finger Protein 431 gene; Zinc finger protein gene; ZNF431 genes

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DefinitionThis section has been translated automatically.

The ZNF431 gene, located on chromosome 19p2, encodes a member of the zinc finger family of Krueppel C2H2 proteins. The encoded protein can negatively regulate transcription of target genes, including the Hedgehog signaling pathway receptor, by interacting with histone deacetylases.

Mutations in the ZNF431 gene may be associated with nonsyndromic facial clefts.

Pathogenic variants in ZNF341 (c.904C>T, NM_001282933.1) are the cause of one of the AR HIES (hyper-IgE syndrome 3; Frey-Jakobs S et al. 2018).

Note(s)This section has been translated automatically.

Zinc finger proteins are a class of nucleic acid-binding proteins that have a specific protein domain, the zinc finger domain, in which a zinc ion (Zn2+) is coordinately bound.

LiteratureThis section has been translated automatically.

  1. Al-Shaikhly T et al (2019) Hyper IgE syndromes: clinical and molecular characteristics. Immunol Cell Biol 97:368-379.

  2. Frey-Jakobs S et al (2018) ZNF341 Controls STAT3 Expression and Thereby Immunocompetence. Sci Immunol 3(24):1-11.

Authors

Last updated on: 14.04.2022

Author: Prof. Dr. med. Peter Altmeyer