Znf431 gene

The ZNF431 gene, located on chromosome 19p2, encodes a member of the zinc finger family of Krueppel C2H2 proteins. The encoded protein can negatively regulate transcription of target genes, including the Hedgehog signaling pathway receptor, by interacting with histone deacetylases.

Mutations in the ZNF431 gene may be associated with nonsyndromic facial clefts.

Pathogenic variants in ZNF341 (c.904C>T, NM_001282933.1) are the cause of one of the AR HIES (hyper-IgE syndrome 3; Frey-Jakobs S et al. 2018).

Zinc finger proteins are a class of nucleic acid-binding proteins that have a specific protein domain, the zinc finger domain, in which a zinc ion (Zn2+) is coordinately bound.

1. Al-Shaikhly T et al (2019) Hyper IgE syndromes: clinical and molecular characteristics. Immunol Cell Biol 97:368-379.

2. Frey-Jakobs S et al (2018) ZNF341 Controls STAT3 Expression and Thereby Immunocompetence. Sci Immunol 3(24):1-11.