Tubulointerstitial kidney diseases N10.-; N11.-

Heterogeneous group of kidney diseases characterized by acute or chronic damage to the tubule apparatus and interstitium. The "interstitial" nephritis got its name due to the histologically detectable inflammatory infiltration of the interstitium and the tubules (T cells, macrophages, isolated granulocytes). Hence the term "tubulointerstitial".

Depending on the clinical course, a distinction is made:

• Acute tubulointerstitial nephritis (N10.-)
• Chronic tubulointerstitial nephritis (N11.-)

The tubulointerstitial nephritis is the most common disease in nephrology. In its primary form it is responsible for 15% of cases of acute renal failure and 25% of cases of chronic renal failure. In its secondary form, it can also develop as a result of glomerular or vascular damage.

Etio: Tubulointerstitial kidney disease can cause:

• primarily as a consequence of primary damage to the tubuline intitium
• or
• secondary as a result of a renovascular disease

The irreversible final stage of all kidney diseases is chronic interstitial fibrosis.