Tsh receptor antibody

TSH receptor antibodies belong to the class of IgG antibodies (IgG autoantibodies) that are directed against the TSH receptor on thyroid cells. They bind to the TSH receptor (TSH-R) and lead to an uncontrolled stimulation of the receptor. They therefore have an analogous effect to the physiologically binding hormone"thyroid-stimulating hormone" (TSH).

TSH receptor antibodies occur primarily in hyperthyroidism of the Graves' disease type (autoimmune thyroid disease with goitre, hyperthyroidism and endocrine orbitopathy).

Graves' disease: TRAK detection rate: 80-100 %

Postpartum thyroiditis: Special form of chronic thyroiditis that occurs after childbirth. This results in temporary hyperthyroidism (hyperthyroidism), which is followed by temporary hypothyroidism with spontaneous recovery. TRAK detection frequency: 50-70 %

Hashimoto thyroiditis (Hashimoto thyroiditis; autoimmune thyroiditis); autoimmune disease of the thyroid gland that leads to hypothyroidism (underactive thyroid gland). TRAK detection frequency: approx. 10 %

Primary myxedema (atrophic autoimmune thyroiditis). TRAK detection rate: 0-5 %

Thyroid autonomy (rare). TRAK detection frequency: approx. 5 %

Healthy persons. TRAK detection frequency in healthy individuals: 0 %

Thyrotropin receptor autoantibodies differ from most other autoantibodies (e.g. ANA; ENA) because they are directly responsible for the clinical symptoms of the disease.