DefinitionThis section has been translated automatically.
TRP V3 is the acronym for "Transient receptor potential vanilloid-3", a receptor protein that functions as a heat receptor.
General informationThis section has been translated automatically.
However, the perception of moderate, non-painful warmth (34-42°C), mediated by specialized sensory fibers innervating the skin, tongue and nose, is also important for the survival of the organism.
TRPV3 is 40% identical to TRPV1.
The activation temperature for TRPV3 is around 34-38°C, with increasing activation at higher noxious temperatures.
Thus, the channel is already activated by moderate heat but also by heat. In contrast to TRPV1, the channel becomes noticeably sensitized to repeated heat stimuli. It could thus serve as a warning signal against potentially tissue-damaging stimuli for the body.
It is conceivable that TRPV3 modulate TRPV1 responses.
